This dataset provides estimates of the impact of COVID-19 on routine childhood immunizations (DTP3 and MCV1) monthly in 2020 by country, Global Burden of Disease (GBD) super-region, and globally. Indicators include mean and 95% uncertainty intervals for the estimated relative disruption attributable to COVID-19, estimated coverage, and expected coverage in the absence of COVID-19 for all locations and estimated doses missed, expected doses missed in the absence of COVID-19, and estimated doses missed attributable to COVID-19 for global and GBD super-region locations. These estimates were produced using administrative data and reports from electronic immunization systems, with mobility data as a model input.