This dataset contains aggregated indicators calculated using self-report survey data from more than 621,000 people in 21 countries aged 18 years and up collected from March-May 2023. Data were collected through a stratified random sampling approach of Facebook users via a Qualtrics platform. Questionnaires were translated into 15 languages and survey weights were calculated to help correct for sampling bias. Indicator topics include access to health care, trust in governmental organizations, vaccine confidence, financial security, food security, education, COVID-19 vaccination status, childhood routine immunizations, and demographic and behavioral variables.